Propranolol-induced Involution of Infantile Hemangioma

A 4-week-old girl with infantile (capillary) hemangioma involving the periocular area (A) underwent a 12-month course of oral propranolol, leading to significant involution (B). The residual lesion, unresponsive to propranolol, was excised to treat anisometropic amblyopia. Histopathologic evaluation revealed lobules of capillary-sized vascular channels lined by flattened endothelium that expressed glucose transporter-1 (GLUT1), compatible with infantile hemangioma (arrow), adjacent to non-lesional GLUT1-negative vessels (arrowheads) (C, original magnification ×100).