离解的
离解(化学)
心理学
功能磁共振成像
默认模式网络
神经科学
分离障碍
感兴趣区域
精神病理学
人口
规范性
静息状态功能磁共振成像
功能连接
临床心理学
医学
化学
环境卫生
物理化学
放射科
哲学
认识论
作者
Saurabh Bhaskar Shaw,Braeden A. Terpou,Maria Densmore,Jean Théberge,Paul Frewen,Margaret C. McKinnon,Ruth A. Lanius
标识
DOI:10.1038/s44220-023-00115-y
摘要
The dissociative subtype of post-traumatic stress disorder (PTSD) is a distinct PTSD phenotype characterized by trauma-related dissociation, alongside unique patterns of functional connectivity. However, disparate findings across multiple scales of investigation have highlighted the need for a cohesive understanding of dissociative neurobiology. We took a step towards this goal by conducting one of the broadest region of interest (ROI)-to-ROI analyses performed on a PTSD population to date. In this retrospective study, we investigated resting-state functional MRI data collected from a total of 192 participants, 134 of whom were diagnosed with PTSD. Small functional connectivity differences (maximum effect size 0.27) were found between participants with PTSD and controls in the temporal regions and the right frontoparietal network. Participants with the dissociative subtype showed a markedly different pattern of widespread functional hyperconnectivity compared with controls (maximum effect size 0.46), spanning subcortical regions, sensorimotor and other intrinsic connectivity networks. Furthermore, analysis of latent dimensions underlying both ROI-to-ROI brain results and a range of behavioral and clinical measures identified three clinically relevant latent dimensions—two linked to dissociation and one linked to PTSD symptoms. These results advance our understanding of dissociative neurobiology, characterizing it as a divergence from normative small-world organization. These patterns of hyperconnectivity are thought to serve a compensatory function to preserve global brain functioning in participants experiencing trauma-related dissociation. The authors used region of interest (ROI)-to-ROI analysis to investigate functional connectivity patterns in patients with post-traumatic stress disorder (PTSD) and its dissociative subtype compared with healthy controls.
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