吡罗昔康
骨关节炎
滑液
类风湿性关节炎
医学
关节炎
松弛法
磁共振成像
内科学
病理
放射科
自旋回波
替代医学
作者
Arturo Elías-Llumbet,Yuchen Tian,Claudia Reyes-San-Martin,Alejandro Reina-Mahecha,Viraj Damle,Aryan Morita,Hugo C. van der Veen,Prashant K. Sharma,Maria Sandovici,Aldona Mzyk,Romana Schirhagl
出处
期刊:Nano Letters
[American Chemical Society]
日期:2023-09-07
卷期号:23 (18): 8406-8410
标识
DOI:10.1021/acs.nanolett.3c01506
摘要
Diamond-based T1 relaxometry is a new technique that allows nanoscale magnetic resonance measurements. Here we present its first application in patient samples. More specifically, we demonstrate that relaxometry can determine the free radical load in samples from arthritis patients. We found that we can clearly differentiate between osteoarthritis and rheumatoid arthritis patients in both the synovial fluid itself and cells derived from it. Furthermore, we tested how synovial fluid and its cells respond to piroxicam, a common nonsteroidal anti-inflammatory drug (NSAID). It is known that this drug leads to a reduction in reactive oxygen species production in fibroblast-like synoviocytes (FLS). Here, we investigated the formation of free radicals specifically. While FLS from osteoarthritis patients showed a drastic decrease in the free radical load, cells from rheumatoid arthritis retained a similar radical load after treatment. This offers a possible explanation for why piroxicam is more beneficial for patients with osteoarthritis than those with rheumatoid arthritis.
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