化学
亲核细胞
立体化学
群(周期表)
选择性
药物化学
有机化学
催化作用
作者
Yongliang Zhang,Changsheng Chen,Yongtao Gao,Min Yang,Zehuan He,Bangzhi Zhang,Guofeng Gu,Bencan Tang,Feng Cai
出处
期刊:Organic Letters
[American Chemical Society]
日期:2023-09-22
卷期号:25 (39): 7120-7125
被引量:6
标识
DOI:10.1021/acs.orglett.3c02566
摘要
eq-4-O-Acyl group directed β-rhamnosylation and β-mannosylation are achieved in a carborane or BARF anion formed weakly nucleophilic environment with the assistance of a 2,3-orthocarbonate group. The 4-O-acyl group plays a critical role in directing the β-selectivity, and the weakly coordinating anion is essential to amplify this direction. The orthocarbonate group could be readily removed with 1,3-propanediol in the presence of BF3·Et2O.
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