2型糖尿病
非酒精性脂肪肝
医学
孟德尔随机化
内科学
糖尿病
脂肪肝
胃肠病学
内分泌学
疾病
基因型
生物
基因
遗传学
遗传变异
作者
Xuetong Ni,Chao Tong,Aheyeerke Halengbieke,Tengrui Cao,Jianmin Tang,Lixin Tao,Deqiang Zheng,Yumei Han,Qiang Li,Xinghua Yang
标识
DOI:10.1016/j.diabres.2023.110993
摘要
The aim of this study was to explore the mutually causal relationship between NAFLD and type 2 diabetes.Based on the data obtained from GWAS, this study employed bidirectional two-sample MR analysis to investigate the causal relationship between NAFLD and type 2 diabetes, and also examined the causal relationship between liver fat accumulation and type 2 diabetes as well as the relationship between NAFLD and FPG, IR.In MR analysis of NAFLD and type 2 diabetes, when NAFLD as an exposure and type 2 diabetes as a result, the OR (95 % CI) was 1.10890 (1.00135-1.22801); in the reverse analysis, the OR value was not statistically significant. In MR analysis of NAFLD, FPG and IR, there was no statistical significance in both directions. In MR analysis of liver fat accumulation and type 2 diabetes, when liver fat as an exposure and type 2 diabetes as a result, the OR (95 % CI) was 1.17516 (1.02054-1.35321); in the reverse analysis, the OR value (95 % CI) was 1.06283 (1.02879-1.09799).There is a unidirectional causal relationship between NAFLD and type 2 diabetes. Furthermore, a bidirectional causal relationship exists between liver fat accumulation and type 2 diabetes.
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