Alpha-lipoic Acid Protects Against Chronic Alcohol Consumption-induced Cardiac Damage by the Aldehyde Dehydrogenase 2–associated PINK/Parkin Pathway

粒体自噬 氧化应激 内科学 内分泌学 医学 帕金 肌酸激酶 心肌病 醛脱氢酶 化学 生物化学 心力衰竭 细胞凋亡 疾病 自噬 帕金森病
作者
Cheng Shen,Xueheng Chen,Yong Cao,Yanyan Du,Xuan Xu,Qingjing Wu,Lizhi Lin,Yiran Qin,Runqi Meng,Lijun Gan,Jinguo Zhang
出处
期刊:Journal of Cardiovascular Pharmacology [Ovid Technologies (Wolters Kluwer)]
卷期号:82 (5): 407-418 被引量:3
标识
DOI:10.1097/fjc.0000000000001480
摘要

Abstract Chronic alcohol intake contributes to high mortality rates due to ethanol-induced cardiac hypertrophy and contractile dysfunction, which are accompanied by increased oxidative stress and disrupted mitophagy. Alpha-lipoic acid (α-LA), a well-known antioxidant, has been shown to protect against cardiac hypertrophy and inflammation. However, little is known about its role and mechanism in the treatment of alcoholic cardiomyopathy. Here, we evaluated the role of α-LA in alcohol-induced cardiac damage by feeding mice a 4.8% (v/v) alcohol diet with or without α-LA for 6 w. Our results suggested that chronic alcohol consumption increased mortality, blood alcohol concentrations, and serum aldehyde levels, but a-LA attenuated the elevations in mortality and aldehydes. Chronic alcohol intake also induced cardiac dysfunction, including enlarged left ventricles, reduced left ventricular ejection fraction, enhanced cardiomyocyte size, and increased serum levels of brain natriuretic peptide, lactate dehydrogenase, and creatine kinase myocardial isoenzyme. Moreover, alcohol intake led to the accumulation of collagen fiber and mitochondrial dysfunction, the effects of which were alleviated by α-LA. In addition, α-LA intake also prevented the increase in reactive oxygen species production and the decrease in mitochondrial number that were observed after alcohol consumption. Chronic alcohol exposure activated PINK1/Parkin-mediated mitophagy. These effects were diminished by α-LA intake by the activation of aldehyde dehydrogenase 2. Our data indicated that α-LA helps protect cardiac cells against the effects of chronic alcohol intake, likely by inhibiting PINK1/Parkin-related mitophagy through the activation of aldehyde dehydrogenase 2.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
ARXC发布了新的文献求助10
2秒前
芽芽豆完成签到 ,获得积分10
4秒前
微笑诗蕊发布了新的文献求助30
4秒前
天天快乐应助樊川采纳,获得10
5秒前
6秒前
anna发布了新的文献求助10
6秒前
GHOMON完成签到,获得积分10
7秒前
充电宝应助1111采纳,获得10
8秒前
9秒前
爱因斯坦完成签到,获得积分10
10秒前
菜菜Cc发布了新的文献求助10
10秒前
samar完成签到,获得积分20
10秒前
12秒前
12秒前
丘比特应助Cyril采纳,获得10
13秒前
YYY发布了新的文献求助10
14秒前
韩soso完成签到,获得积分10
15秒前
杜彦君完成签到 ,获得积分10
16秒前
小马想毕业完成签到,获得积分10
17秒前
17秒前
mmyhn发布了新的文献求助10
17秒前
20秒前
卓矢完成签到 ,获得积分10
21秒前
21秒前
ZYYYY发布了新的文献求助10
23秒前
24秒前
画龙点睛完成签到 ,获得积分10
24秒前
1111发布了新的文献求助10
24秒前
菇小小完成签到 ,获得积分10
25秒前
如意曼雁完成签到,获得积分10
25秒前
小巧的诗双完成签到,获得积分10
25秒前
MY完成签到,获得积分10
25秒前
26秒前
28秒前
nkkl完成签到,获得积分10
28秒前
超人会飞233完成签到,获得积分10
28秒前
30秒前
MIA903完成签到 ,获得积分10
30秒前
菇小小关注了科研通微信公众号
31秒前
栗子完成签到,获得积分10
32秒前
高分求助中
Sustainability in Tides Chemistry 2800
The Young builders of New china : the visit of the delegation of the WFDY to the Chinese People's Republic 1000
юрские динозавры восточного забайкалья 800
English Wealden Fossils 700
Foreign Policy of the French Second Empire: A Bibliography 500
Chen Hansheng: China’s Last Romantic Revolutionary 500
XAFS for Everyone 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3143731
求助须知:如何正确求助?哪些是违规求助? 2795219
关于积分的说明 7813671
捐赠科研通 2451210
什么是DOI,文献DOI怎么找? 1304353
科研通“疑难数据库(出版商)”最低求助积分说明 627221
版权声明 601400