代谢组学
代谢组
肾结石
尿酸
马尿酸
尿
化学
草酸盐
代谢物
草酸钙
发病机制
生物化学
医学
色谱法
内科学
有机化学
作者
Nicholas S. Kowalczyk,Megan Prochaska,Elaine M. Worcester
出处
期刊:Current Opinion in Nephrology and Hypertension
[Ovid Technologies (Wolters Kluwer)]
日期:2023-07-21
卷期号:32 (5): 490-495
被引量:1
标识
DOI:10.1097/mnh.0000000000000903
摘要
Purpose of review Kidney stone disease is caused by supersaturation of urine with certain metabolites and minerals. The urine composition of stone formers has been measured to prevent stone recurrence, specifically calcium, uric acid, oxalate, ammonia, citrate. However, these minerals and metabolites have proven to be unreliable in predicting stone recurrence. Metabolomics using high throughput technologies in well defined patient cohorts can identify metabolites that may provide insight into the pathogenesis of stones as well as offer possibilities in therapeutics. Recent findings Techniques including 1 H - NMR, and liquid chromatography paired with tandem mass spectroscopy have identified multiple possible metabolites involved in stone formation. Compared to formers of calcium oxalate stones, healthy controls had higher levels of hippuric acid as well as metabolites involved in caffeine metabolism. Both the gut and urine microbiome may contribute to the altered metabolome of stone formers. Summary Although metabolomics has offered several potential metabolites that may be protective against or promote stone formation, the mechanisms behind these metabolomic profiles and their clinical significance requires further investigation.
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