生物
肾
免疫学
免疫系统
促炎细胞因子
背景(考古学)
肾脏病理学
炎症
免疫
细胞因子
内分泌学
古生物学
作者
Doureradjou Peroumal,Partha S. Biswas
出处
期刊:Annual Review of Immunology
[Annual Reviews]
日期:2023-10-31
卷期号:42 (1)
标识
DOI:10.1146/annurev-immunol-052523-015141
摘要
The kidneys are life-sustaining organs that are vital to removing waste from our body. Because of their anatomic position and high blood flow, the kidneys are vulnerable to damage due to infections and autoinflammatory conditions. Even now, our knowledge of immune responses in the kidney is surprisingly rudimentary. Studying kidney-specific immune events are challenging because of the poor regenerative capacity of the nephrons, accumulation of uremic toxins, and hypoxia- and arterial blood pressure–mediated changes, all of which have unexpected positive or negative impacts on the immune response in the kidney. Kidney-specific defense confers protection against pathogens. On the other hand, unresolved inflammation leads to kidney damage and fibrosis. Interleukin-17 is a proinflammatory cytokine that has been linked to immunity against pathogens and pathogenesis of autoinflammatory diseases. In this review, we discuss current knowledge of IL-17 activities in the kidney in the context of infections, autoinflammatory diseases, and renal fibrosis. Expected final online publication date for the Annual Review of Immunology, Volume 42 is April 2024. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
科研通智能强力驱动
Strongly Powered by AbleSci AI