NLRP12 senses heme and PAMPs to drive necrotic cell death and inflammation

Red blood cell rupture (hemolysis) activates innate immunity and inflammation by releasing heme. Sundaram et al. 1 Sundaram B. Pandian N. Mall R. Wang Y. Sarkar R. Kim H.J. Malireddi R.K.S. Karki R. Janke L.J. Vogel P. Kanneganti T.D. NLRP12-PANoptosome activates PANoptosis and pathology in response to heme and PAMPs. Cell. 2023; 186: 2783-2801.e20https://doi.org/10.1016/j.cell.2023.05.005 Abstract Full Text Full Text PDF PubMed Scopus (25) Google Scholar implicate the immune sensor NLRP12 in hemolytic disease, showing that it controls necrotic cell death induction in response to heme combined with pathogen-associated molecules. Red blood cell rupture (hemolysis) activates innate immunity and inflammation by releasing heme. Sundaram et al. 1 Sundaram B. Pandian N. Mall R. Wang Y. Sarkar R. Kim H.J. Malireddi R.K.S. Karki R. Janke L.J. Vogel P. Kanneganti T.D. NLRP12-PANoptosome activates PANoptosis and pathology in response to heme and PAMPs. Cell. 2023; 186: 2783-2801.e20https://doi.org/10.1016/j.cell.2023.05.005 Abstract Full Text Full Text PDF PubMed Scopus (25) Google Scholar implicate the immune sensor NLRP12 in hemolytic disease, showing that it controls necrotic cell death induction in response to heme combined with pathogen-associated molecules.