[Research Progress of Short Chain Fatty Acids in the Pathogenesis of Immune Thrombocytopenia--Review].

The gut microbiota is an important part of the human body, and it's also the largest genome in the human body. Recent studies on the gut microbiota have found that it plays an important role in human immune diseases. In recent years, the methods of sequencing gut microbiota has teen improved, thus dysregulation of the gut microbiota is found in many immune diseases, and the most widely studied mechanism is the short-chain fatty acids (SCFA), which is a metabolite of gut microbiota. The role of short-chain fatty acids in intestinal barrier, IgA immunity, dendritic cells and regulatory T cells has become increasingly clear. The mechanisms of short-chain fatty acids in regulating immunity and its role in the pathogenesis of immune thrombocytopenia were covered in this review, so as to provide a new idea for the treatment of immune thrombocytopenia in the future.短链脂肪酸在免疫性血小板减少症发病机制中的研究进展.肠道菌群是人体重要组成部分，也是人体内最庞大的基因组。近几年对肠道菌群的研究发现，肠道菌群在人类免疫性疾病中扮演重要角色。随着肠道菌群测序方法的改进，越来越多的研究发现肠道菌群失调在众多免疫性疾病中存在，而其中的相关机制研究最广泛的是肠道菌群代谢物短链脂肪酸。短链脂肪酸对肠道屏障、IgA免疫、树突状细胞及调节性T细胞等的作用越来越明确。本文综述了短链脂肪酸调节免疫的机制，以及短链脂肪酸可能在免疫性血小板减少症发病中起到的作用，为以后免疫性血小板减少症的治疗提供新的研究思路。.