化学
芳构化
级联
组合化学
试剂
联轴节(管道)
吡啶
催化作用
计算化学
立体化学
有机化学
机械工程
色谱法
工程类
作者
Yu Liu,Qiujian Tan,Lan Bao,Yun Nie,Lianshun Zhang,Zhongyan Hu,Xianxiu Xu
出处
期刊:Organic Letters
[American Chemical Society]
日期:2024-06-06
卷期号:26 (23): 5043-5048
标识
DOI:10.1021/acs.orglett.4c01699
摘要
Herein, we present a new and general protocol for the assembly of 2,2′-bipyridyls from nonpyridine substrates without using any metal catalysts or organometallic reagents. The process starts from the coupling of two 1,3-dienyl isocyanides followed by a 6π-electrocyclization/aromatization cascade featuring the simultaneous formation of two pyridine rings in a single operation. Notably, this strategy is also applicable to the construction of nonsymmetrical 2-(2-pyridyl)-quinolines/-quinoxalines. Furthermore, the aggregation-induced emission (AIE) characteristics endow our approach with great potential in biorelevant fields.
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