生物
免疫学
表位
抗原
抗体
免疫球蛋白E
人口
食物过敏
背景(考古学)
免疫系统
免疫球蛋白G
过敏
医学
环境卫生
古生物学
作者
Sigal Leviatan,Thomas Vogl,Shelley Klompus,Iris Kalka,Adina Weinberger,Eran Segal
出处
期刊:Immunity
[Elsevier]
日期:2022-12-01
卷期号:55 (12): 2454-2469.e6
被引量:19
标识
DOI:10.1016/j.immuni.2022.11.004
摘要
Although food-directed immunoglobulin E (IgE) has been studied in the context of allergies, the prevalence and magnitude of IgG responses against dietary antigens are incompletely characterized in the general population. Here, we measured IgG binding against food and environmental antigens obtained from allergen databases and the immune epitope database (IEDB), represented in a phage displayed library of 58,233 peptides. By profiling blood samples of a large cohort representing the average adult Israeli population (n = 1,003), we showed that many food antigens elicited systemic IgG in up to 50% of individuals. Dietary intake of specific food protein correlated with antibody binding, suggesting that diet can shape the IgG epitope repertoire. Our work documents abundant systemic IgG responses against food antigens and provides a reference map of the exact immunogenic epitopes on a population scale, laying the foundation to unravel the role of food- and environmental antigen-directed antibody binding in disease contexts.
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