生物
妊娠期糖尿病
蔷薇花
普雷沃菌属
肠道菌群
代谢组学
普氏粪杆菌
代谢组
拟杆菌
真细菌
失调
胰岛素抵抗
微生物群
内分泌学
内科学
生理学
糖尿病
生物信息学
免疫学
怀孕
医学
细菌
遗传学
妊娠期
作者
Dewei Ye,Jiating Huang,Jiaming Wu,Kang Xie,Xiang Gao,Kaixuan Yan,Pengfei Zhang,Ying Tao,Yun Li,Shufei Zang,Xianglu Rong,Jun Li,Jiao Guo
出处
期刊:Gut microbes
[Informa]
日期:2022-12-22
卷期号:15 (1)
被引量:23
标识
DOI:10.1080/19490976.2022.2154552
摘要
Gestational diabetes mellitus (GDM) is characterized by the development of hyperglycemia and insulin resistance during the second or third trimester of pregnancy, associated with considerable risks to both the mother and developing fetus. Although emerging evidence suggests an association between the altered gut microbiota and GDM, remarkably little is known about the microbial and metabolic mechanisms that link the dysbiosis of the gut microbiota to the development of GDM. In this study, a metagenome-wide association study and serum metabolomics profiling were performed in a cohort of pregnant women with GDM and pregnant women with normal glucose tolerance (NGT). We identified gut microbial alterations associated with GDM and linked to the changes in circulating metabolites. Blood metabolite profiles revealed that GDM patients exhibited a marked increase in 2-hydroxybutyric acid and L-alpha-aminobutyric acid, but a decrease in methionine sulfoxide, allantoin, and dopamine and dopaminergic synapse, when compared with those in NGT controls. Short-chain fatty acid-producing genera, including Faecalibacterium, Prevotella, and Streptococcus, and species Bacteroides coprophilus, Eubacterium siraeum, Faecalibacterium prausnitzii, Prevotella copri, and Prevotella stercorea, were significantly reduced in GDM patients relative to those in NGT controls. Bacterial co-occurrence network analysis revealed that pro-inflammatory bacteria were over-represented as the core species in GDM patients. These microbial and metabolic signatures are closely associated with clinical parameters of glucose metabolism in GDM patients and NGT controls. In conclusion, we identified circulating dopamine insufficiency, imbalanced production of SCFAs, and excessive metabolic inflammation as gut microbiota-driven multiple parallel hits linked to GDM development. This work might explain in part the mechanistic link between altered gut microbiota and GDM pathogenesis, and suggest that gut microbiota may serve as a promising target to intervene in GDM.
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