肠道菌群
免疫系统
肠-脑轴
机制(生物学)
肠道细菌
疾病
免疫学
生物
炎症
寄主(生物学)
医学
内科学
生态学
认识论
哲学
作者
Jing Lu,Xiao Jin,Shengjie Yang,Yujuan Li,Xinyue Wang,Min Wu
标识
DOI:10.3389/fmicb.2022.1034537
摘要
The risk of cardiovascular disease (CVD) is associated with unusual changes in the human gut microbiota, most commonly coronary atherosclerotic heart disease, hypertension, and heart failure. Immune mechanisms maintain a dynamic balance between the gut microbiota and the host immune system. When one side changes and the balance is disrupted, different degrees of damage are inflicted on the host and a diseased state gradually develops over time. This review summarizes the immune mechanism of the gut microbiota and its metabolites in the occurrence of common CVDs, discusses the relationship between gut-heart axis dysfunction and the progression of CVD, and lists the currently effective methods of regulating the gut microbiota for the treatment of CVDs.
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