美洛昔康
材料科学
药理学
兽医学
纳米技术
医学
作者
Katherine A. Miranda-Muñoz,Kirsten A Midkiff,Alan E. Woessner,Mahyar Afshar‐Mohajer,Min Zou,Erik D. Pollock,David Gonzalez-Nino,Gary S. Prinz,Lillian Hutchinson,Ruohan Li,Kushan Kompalage,Christopher T. Culbertson,Ryan Tucker,Hans Coetzee,Tsung-Cheng Tsai,Jeremy G Powell,Jorge Almodóvar
出处
期刊:ACS Nano
[American Chemical Society]
日期:2024-09-03
卷期号:18 (37): 25716-25739
标识
DOI:10.1021/acsnano.4c08072
摘要
This study evaluates the use of poly(vinyl alcohol), collagen, and chitosan blends for developing a microneedle patch for the delivery of meloxicam (MEL). Results confirm successful MEL encapsulation, structural integrity, and chemical stability even after ethylene oxide sterilization. Mechanical testing indicates the patch has the required properties for effective skin penetration and drug delivery, as demonstrated by load-displacement curves showing successful penetration of pig ear surfaces at 3N of normal load.
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