Regulation of daptomycin biosynthesis in Streptomyces roseosporus: new insights from genomic analysis and synthetic biology to accelerate lipopeptide discovery and commercial production

Complex regulatory mechanisms govern daptomycin biosynthesis in Streptomyces roseosporus . Ten regulatory genes modulate transcription of daptomycin biosynthetic genes from a single promoter, and translation is coordinated by translational coupling.