单克隆抗体病
不确定意义的单克隆抗体病
医学
单倍型
副蛋白血症
血液学
单克隆
计算生物学
病理
单克隆抗体
免疫学
遗传学
生物
抗体
基因型
基因
作者
Hauke Thomsen,Subhayan Chattopadhyay,Niels Weinhold,Pavel Vodička,Ľudmila Vodičková,Per Hoffmann,Markus M. Nöthen,Martin Dichgans,Ronny Myhre,Roman Hájek,Göran Hallmans,U Pettersson,Florentin Späth,Hartmut Goldschmidt,Kari Hemminki,Asta Försti
标识
DOI:10.1038/s41408-024-01121-8
摘要
Genome-wide association studies (GWASs) based on common single nucleotide polymorphisms (SNPs) have identified several loci associated with the risk of monoclonal gammopathy of unknown significance (MGUS), a precursor condition for multiple myeloma (MM). We hypothesized that analyzing haplotypes might be more useful than analyzing individual SNPs, as it could identify functional chromosomal units that collectively contribute to MGUS risk. To test this hypothesis, we used data from our previous GWAS on 992 MGUS cases and 2910 controls from three European populations. We identified 23 haplotypes that were associated with the risk of MGUS at the genome-wide significance level (p < 5 × 10
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