药物输送
脂质体
纳米颗粒
高分子
毒品携带者
血液循环
胶束
化学
药品
纳米技术
靶向给药
生物物理学
药理学
医学
生物化学
材料科学
生物
有机化学
水溶液
传统医学
作者
Yoshinobu Takakura,Yuki Takahashi
标识
DOI:10.1016/j.jconrel.2022.05.063
摘要
The enhanced permeability and retention (EPR) effect has been the gold standard in developing drug delivery systems for passive tumor targeting. Although the importance of this concept remains unchanged, some controversies have arisen. In this review, various strategies for tumor targeting using macromolecules and nanoparticles based on the EPR effect are discussed from the viewpoint of pharmacokinetics. Overall, such strategies seek to retain therapeutic material in the blood circulation, which is a key factor for successful targeting. Strategies using macromolecules, including antibody–drug conjugates, serum albumin-based delivery systems, PEGylated recombinant proteins, and stealth liposomes as well as nanoparticle-based strategies such as those based on lipid nanoparticles, and polymeric micelles, have been discussed. The feasibility of small extracellular vesicles, a new class of nanosized delivery carriers, is also discussed.
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