二甲双胍
葡萄糖转运蛋白
内科学
糖尿病
内分泌学
链脲佐菌素
胰岛素抵抗
葡萄糖摄取
过剩4
糖原
过剩2
胰岛素
医学
糖原合酶
化学
作者
Atcharaporn Ontawong,Sirinat Pengnet,Arthid Thim-uam,Chutima Srimaroeng,Narongsuk Munkong,Manussaborn Phatsara,Kullanat Kuntakhut,Jakkapong Inchai,Doungporn Amornlerdpison,Teerawat Rattanaphot
标识
DOI:10.1016/j.jtcme.2023.12.003
摘要
Red rice (Oryza sativa L.) consumption has grown recently, partly due to its potential health benefits in several disease prevention. The impact of red rice bran aqueous extract (RRBE) on intestinal glucose uptake and diabetes mellitus (DM) progression has not been thoroughly investigated. This study aimed to evaluate the effect of RRBE on ex vivo intestinal glucose absorption and its potential as an antihyperglycemic compound using a high-fat diet and streptozotocin (STZ)-induced diabetic rats. High-fat diet/STZ-induced diabetic rats were supplemented with either 1000 mg/kg body weight (BW) of RRBE, 70 mg/kg BW of metformin (Met), or a combination of RRBE and Met for 3 months. Plasma parameters, intestinal glucose transport, morphology, liver and soleus muscle glycogen accumulation were assessed. Treatment with RRBE, metformin, or combination markedly reversed hyperglycemia, hypertriglyceridemia, insulin resistance, and pancreatic morphology changes associated with T2DM. Correspondingly, all supplements effectively downregulated glucose transporters, resulting in a reduction of intestinal glucose transport—additionally, liver and soleus muscle glycogen accumulation was reduced in RRBE + Met treated group. Taken together, RRBE potentially suppressed intestinal glucose transporters' function and expression, reducing diabetic status.
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