Fluorene-9-bisphenol exposure damages the testis in mice through a novel mechanism of ferroptosis

氧化应激 男科 精子活力 脂质过氧化 细胞凋亡 精子 生殖毒性 运动性 内分泌系统 DNA损伤 细胞生物学 化学 生物 毒理 内分泌学 毒性 内科学 医学 生物化学 激素 DNA
作者
Qiwen Feng,Yumeng Liu,Liping Zou,Mengying Lei,Changhong Zhu,Wei Xia
出处
期刊:Food and Chemical Toxicology [Elsevier]
卷期号:184: 114385-114385 被引量:5
标识
DOI:10.1016/j.fct.2023.114385
摘要

Fluorene-9-bisphenol (BHPF) is an emerging global endocrine-disrupting chemical found in numerous household products as a substitute of bisphenol A. Many studies have reported various toxicities associated with BHPF. However, the effect of BHPF on male reproduction, particularly on the structural integrity of the blood testis barrier (BTB) in mice, has not yet been extensively studied. Ferroptosis, a newly identified form of cell death, occurs in the testicular tissue following exposure to BPA, affecting male fertility. We investigated whether ferroptosis plays a role in BHPF-induced testicular damage. The findings indicated that BHPF exposure led decreases in serum testosterone (T) concentration and sperm concentration and motility in mice. Furthermore, BHPF disrupted the BTB by interfering with key BTB-related proteins, including Cx43, β-catenin, and ZO-1. Moreover, BHPF induced ferroptosis through the induction of lipid peroxidation, iron overload, oxidative stress, and mitochondrial dysfunction in the testicular tissue. Inhibition of ferroptosis using Fer-1 mitigated the BHPF-induced damage to the BTB and ferroptosis in TM4 cells. Overall, our findings indicated the detrimental effects of BHPF on male reproductive function in mice, suggesting ferroptosis as a mechanism underlying testicular damage.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
CipherSage应助kaneki采纳,获得10
刚刚
刚刚
积德行善SCI无边完成签到,获得积分0
刚刚
今后应助夏果果采纳,获得10
1秒前
生椰拿铁不加生椰完成签到 ,获得积分10
2秒前
3秒前
小虫发布了新的文献求助10
4秒前
周慧玲完成签到 ,获得积分10
4秒前
专注的草丛完成签到,获得积分10
5秒前
5秒前
孤巷的猫完成签到,获得积分10
5秒前
顾矜应助Ting采纳,获得10
6秒前
cqyyy完成签到 ,获得积分10
7秒前
李杰发布了新的文献求助10
7秒前
Cat应助胡豆豆采纳,获得20
8秒前
水若琳完成签到,获得积分10
9秒前
10秒前
10秒前
10秒前
平淡问雁完成签到,获得积分10
13秒前
14秒前
科研通AI2S应助Yara.H采纳,获得10
14秒前
外向语山发布了新的文献求助10
14秒前
16秒前
炙热冰夏发布了新的文献求助10
16秒前
忧郁绝音发布了新的文献求助10
17秒前
桐桐应助羊羊采纳,获得10
18秒前
梧桐断角发布了新的文献求助10
18秒前
ding应助科研通管家采纳,获得10
21秒前
21秒前
21秒前
科研通AI2S应助科研通管家采纳,获得30
21秒前
ziyue应助科研通管家采纳,获得10
21秒前
爆米花应助科研通管家采纳,获得10
21秒前
科研通AI2S应助科研通管家采纳,获得10
22秒前
22秒前
嗯哼应助科研通管家采纳,获得20
22秒前
22秒前
隐形曼青应助科研通管家采纳,获得10
22秒前
上官若男应助科研通管家采纳,获得10
22秒前
高分求助中
Sustainability in Tides Chemistry 1500
TM 5-855-1(Fundamentals of protective design for conventional weapons) 1000
CLSI EP47 Evaluation of Reagent Carryover Effects on Test Results, 1st Edition 800
Threaded Harmony: A Sustainable Approach to Fashion 799
Livre et militantisme : La Cité éditeur 1958-1967 500
Retention of title in secured transactions law from a creditor's perspective: A comparative analysis of selected (non-)functional approaches 500
"Sixth plenary session of the Eighth Central Committee of the Communist Party of China" 400
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3055485
求助须知:如何正确求助?哪些是违规求助? 2712292
关于积分的说明 7430453
捐赠科研通 2357116
什么是DOI,文献DOI怎么找? 1248604
科研通“疑难数据库(出版商)”最低求助积分说明 606750
版权声明 596093