Relationships of Proton Pump Inhibitor‐Induced Renal Injury with CYP2C19 Polymorphism: A Retrospective Cohort Study

CYP2C19型 埃索美拉唑 兰索拉唑 雷贝拉唑 医学 内科学 胃肠病学 回顾性队列研究 质子抑制剂泵 肾功能 药理学 奥美拉唑 细胞色素P450 新陈代谢
作者
Rika Fukui,Satoshi Noda,Yoshito Ikeda,Yuichi Sawayama,Tomohiro Terada,Yoshihisa Nakagawa,Shin–ya Morita
出处
期刊:Clinical Pharmacology & Therapeutics [Wiley]
卷期号:115 (5): 1141-1151 被引量:2
标识
DOI:10.1002/cpt.3183
摘要

Proton pump inhibitors (PPIs) have recently been reported to be linked with nephrotoxicity. PPIs are metabolized mainly or partly by cytochrome P450 2C19 (CYP2C19). However, the relationship between CYP2C19 genetic polymorphism and PPI-induced nephrotoxicity is unclear. In this study, we aimed to analyze the association between the time of occurrence of renal injury by PPIs, including lansoprazole, esomeprazole, rabeprazole, and vonoprazan, and CYP2C19 metabolizer status classified by CYP2C19 genotypes. Patients prescribed PPIs were reviewed in this retrospective cohort study. The primary outcome was the time to a 30% decrease in estimated glomerular filtration rate (eGFR) from baseline. In patients treated with lansoprazole, the time to a 30% decrease in eGFR for the CYP2C19 poor metabolizer (PM) group was significantly shorter than that for the non-PM group (hazard ratio for PM vs. non-PM, 2.43, 95% confidence interval, 1.21 to 4.87, P = 0.012). In contrast, in patients that received esomeprazole, rabeprazole, or vonoprazan, no significant differences were found in the time to a 30% decrease in eGFR between non-PM and PM groups. The adjusted hazard ratios for the time to a 30% eGFR decrease in patients treated with lansoprazole were significantly higher for CYP2C19 PM, hypertension, and a history of myocardial infarction. In conclusion, this retrospective study showed that CYP2C19 metabolizer status was associated with the time to a 30% eGFR decrease in patients treated with lansoprazole, but not with esomeprazole, rabeprazole, or vonoprazan.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
12345678完成签到,获得积分10
1秒前
福缘发布了新的文献求助10
2秒前
t团子发布了新的文献求助10
3秒前
芒果柠檬发布了新的文献求助10
4秒前
4566发布了新的文献求助10
5秒前
CA完成签到,获得积分10
5秒前
czh应助科研通管家采纳,获得10
5秒前
逆时针应助科研通管家采纳,获得30
5秒前
科研通AI2S应助科研通管家采纳,获得20
5秒前
Hello应助科研通管家采纳,获得10
5秒前
郭小宝发布了新的文献求助10
5秒前
乐乐应助科研通管家采纳,获得10
5秒前
科研通AI5应助科研通管家采纳,获得30
5秒前
longhang应助科研通管家采纳,获得10
5秒前
完美世界应助科研通管家采纳,获得10
6秒前
ding应助科研通管家采纳,获得10
6秒前
小马甲应助科研通管家采纳,获得10
6秒前
小蘑菇应助科研通管家采纳,获得10
6秒前
6秒前
科研通AI5应助科研通管家采纳,获得10
6秒前
完美世界应助科研通管家采纳,获得10
6秒前
ding应助科研通管家采纳,获得10
6秒前
芬栀发布了新的文献求助10
6秒前
彭栋发布了新的文献求助10
7秒前
科目三应助YJ888采纳,获得10
7秒前
顾矜应助girl采纳,获得10
8秒前
徐哈哈完成签到,获得积分10
9秒前
9秒前
阿朱完成签到,获得积分10
9秒前
牛马研究生完成签到,获得积分20
10秒前
昭昭完成签到,获得积分10
10秒前
4566完成签到,获得积分10
11秒前
所所应助牛马码字员采纳,获得10
15秒前
昭昭发布了新的文献求助10
16秒前
君衡完成签到 ,获得积分10
17秒前
潇湘雪月发布了新的文献求助10
17秒前
19秒前
754完成签到,获得积分10
19秒前
SciGPT应助芒果柠檬采纳,获得10
20秒前
芬栀完成签到,获得积分10
21秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989242
求助须知:如何正确求助?哪些是违规求助? 3531393
关于积分的说明 11253753
捐赠科研通 3270010
什么是DOI,文献DOI怎么找? 1804868
邀请新用户注册赠送积分活动 882084
科研通“疑难数据库(出版商)”最低求助积分说明 809136