Effects of nicotinamide mononucleotide on older patients with diabetes and impaired physical performance: A prospective, placebo‐controlled, double‐blind study

医学 握力 安慰剂 不利影响 置信区间 烟酰胺 烟酰胺单核苷酸 糖尿病 内科学 胃肠病学 物理疗法 内分泌学 生物化学 NAD+激酶 烟酰胺腺嘌呤二核苷酸 替代医学 病理 化学
作者
Hiroshi Akasaka,Hironori Nakagami,Ken Sugimoto,Yukiko Yasunobe,Tomohiro Minami,Taku Fujimoto,Kōichi Yamamoto,Chikako Hara,Akihiko Shiraki,Kohji Nishida,Kento Asano,Masanobu Kanou,Kei Yamana,Shin‐ichiro Imai,Hiromi Rakugi
出处
期刊:Geriatrics & Gerontology International [Wiley]
卷期号:23 (1): 38-43 被引量:17
标识
DOI:10.1111/ggi.14513
摘要

Objective Nicotinamide adenine dinucleotide regulates various biological processes. Nicotinamide mononucleotide (NMN) increases its intracellular levels and counteracts age‐associated changes in animal models. We investigated the safety and efficacy of oral nicotinamide mononucleotide supplementation in older patients with diabetes and impaired physical performance. Method We carried out a 24‐week placebo‐controlled, double‐blinded study of male patients with diabetes aged ≥65 years with reduced grip strength (<26 kg) or walking speed (<1.0 m/s). The primary end‐points were to determine the safety of NMN oral administration (250 mg/day), and changes in grip strength and walking speed. The secondary end‐points were to determine the changes in various exploratory indicators. Results We studied 14 participants aged 81.1 ± 6.4 years. NMN was tolerable without any severe adverse events. The changes in grip strength and walking speed showed no difference between the two groups: 1.25 kg (95% confidence interval −2.31 to 4.81) and 0.033 m/s (−0.021 to 0.087) in the NMN group, and −0.44 kg (−4.15 to 3.26) and 0.014 m/s (−0.16 to −0.13) in the placebo group, respectively. There were no significant differences in any exploratory indicators between the two groups. However, improved prevalence of frailty in the NMN group ( P = 0.066) and different changes in central retinal thickness between the two groups ( P = 0.051) was observed. Conclusion In older male patients with diabetes and impaired physical performance, NMN supplementation for 24 weeks was safe, but did not improve grip strength and walking speed. Geriatr Gerontol Int 2023; 23: 38–43 .
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
feizhuliu发布了新的文献求助10
1秒前
chengli完成签到,获得积分10
1秒前
2秒前
You完成签到,获得积分10
2秒前
2秒前
JamesPei应助南柯一梦采纳,获得10
4秒前
4秒前
4秒前
李李完成签到,获得积分10
4秒前
5秒前
尺素寸心完成签到,获得积分10
6秒前
6秒前
吉羿发布了新的文献求助10
6秒前
SC武完成签到,获得积分10
7秒前
7秒前
南卡发布了新的文献求助10
7秒前
脑洞疼应助yy采纳,获得10
7秒前
要减肥的涑完成签到,获得积分20
7秒前
852应助帅男采纳,获得10
8秒前
李芬发布了新的文献求助10
8秒前
彼岸@发布了新的文献求助10
8秒前
hino完成签到 ,获得积分10
9秒前
lanran214发布了新的文献求助10
9秒前
夙夙发布了新的文献求助10
9秒前
10秒前
zhuyt完成签到,获得积分10
12秒前
旭日发布了新的文献求助10
12秒前
eyu完成签到,获得积分10
12秒前
JamesPei应助陈什么烨采纳,获得10
13秒前
weilu关注了科研通微信公众号
14秒前
吴旭东发布了新的文献求助10
14秒前
量子星尘发布了新的文献求助10
15秒前
Krystal完成签到,获得积分10
15秒前
16秒前
18秒前
feizhuliu完成签到,获得积分20
18秒前
Akim应助喻紫寒采纳,获得10
18秒前
高挑的觅山完成签到,获得积分10
18秒前
彼岸@完成签到,获得积分10
20秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3988786
求助须知:如何正确求助?哪些是违规求助? 3531116
关于积分的说明 11252493
捐赠科研通 3269766
什么是DOI,文献DOI怎么找? 1804771
邀请新用户注册赠送积分活动 881870
科研通“疑难数据库(出版商)”最低求助积分说明 809021