人工细胞
生物
合成生物学
人工生命
仿生材料
纳米技术
功能(生物学)
原细胞
生化工程
桥(图论)
领域(数学)
计算机科学
生命系统
化学
人工智能
工程类
生物
计算生物学
材料科学
细胞生物学
膜
生物化学
解剖
数学
纯数学
作者
Haisheng Peng,Man Zhao,Xiaoying Liu,Tianjian Tong,Wenyuan Zhang,Chen Gong,Ratul Chowdhury,Qun Wang
标识
DOI:10.1021/acs.chemrev.4c00241
摘要
As the foundation of life, a cell is generally considered an advanced microreactor with a complicated structure and function. Undeniably, this fascinating complexity motivates scientists to try to extricate themselves from natural living matter and work toward rebuilding artificial cells in vitro. Driven by synthetic biology and bionic technology, the research of artificial cells has gradually become a subclass. It is not only held import in many disciplines but also of great interest in its synthesis. Therefore, in this review, we have reviewed the development of cell and bionic strategies and focused on the efforts of bottom-up strategies in artificial cell construction. Different from starting with existing living organisms, we have also discussed the construction of artificial cells based on biomimetic materials, from simple cell scaffolds to multiple compartment systems, from the construction of functional modules to the simulation of crucial metabolism behaviors, or even to the biomimetic of communication networks. All of them could represent an exciting advance in the field. In addition, we will make a rough analysis of the bottlenecks in this field. Meanwhile, the future development of this field has been prospecting. This review may bridge the gap between materials engineering and life sciences, forming a theoretical basis for developing various life-inspired assembly materials.
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