亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Adipose Mesenchymal Stem Cell-Derived Exosomes as Nanocarriers for Treating Musculoskeletal Disorders

纳米载体 间充质干细胞 微泡 脂肪组织 医学 材料科学 纳米技术 纳米颗粒 化学 小RNA 病理 内科学 生物化学 基因
作者
Ao Tang,Qing Shu,Shaohui Jia,Zhihao Lai,Jun Tian
出处
期刊:International Journal of Nanomedicine [Dove Medical Press]
卷期号:Volume 19: 13547-13562
标识
DOI:10.2147/ijn.s486622
摘要

Musculoskeletal disorders are a series of diseases involving bone, muscle, cartilage, and tendon, mainly caused by chronic strain, degenerative changes, and structural damage due to trauma. The disorders limit the function of patients due to pain and significantly reduce their quality of life. In recent years, adipose-derived mesenchymal stem cells have been extensively applied in regeneration medicine research due to their particular abilities of self-renewal, differentiation, and targeted homing and are more easily accessed compared with other sources. The paracrine effect of ADSCs plays a crucial role in intercellular communication by releasing mass mediators, including cytokines and growth factors, particularly the exosomes they secrete. Not only do these exosomes possess low immunogenicity, low toxicity, and an enhanced ability to penetrate a bio-barrier, but they also inherit their parent cells' characteristics and carry various bioactive molecules to release to targeted cells, modulating their biological process. Meanwhile, these characteristics also make exosomes a natural nanocarrier capable of targeted drug delivery to specific sites, enhancing the bioavailability of drugs within the body and achieving precision therapy with fewer toxic side effects. Furthermore, the integration of exosomes with tissue engineering and chemical modification strategies can also significantly enhance their efficacy in facilitating tissue repair. However, the current research on ADSC-Exos for improving MSDs remains at an early stage and needs further exploration. Therefore, this review summarized the ADSC-Exo as a nanodrug carrier characteristics and mechanism in the treatment of fracture, osteoporosis, osteoarthritis, intervertebral disc degeneration, and tendon injury, which push forward the research progress of ADSC-Exo therapy for MSDs.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
大方大船完成签到,获得积分10
6秒前
谦让幻珊发布了新的文献求助10
7秒前
温柔灵波完成签到 ,获得积分10
8秒前
田様应助科研通管家采纳,获得10
11秒前
李爱国应助科研通管家采纳,获得10
11秒前
11秒前
12秒前
可爱的函函应助谦让幻珊采纳,获得10
13秒前
ding应助江洋大盗采纳,获得10
18秒前
Song完成签到 ,获得积分10
18秒前
谦让幻珊完成签到,获得积分10
20秒前
嗨好发布了新的文献求助20
26秒前
32秒前
沈惠映完成签到 ,获得积分10
32秒前
38秒前
嗨好完成签到,获得积分10
38秒前
Isaac完成签到 ,获得积分10
40秒前
莹yy完成签到 ,获得积分10
40秒前
乐正亦寒完成签到 ,获得积分10
51秒前
斯文败类应助haha采纳,获得10
54秒前
Swear完成签到 ,获得积分10
59秒前
1分钟前
1分钟前
1分钟前
JingjingYao发布了新的文献求助10
1分钟前
行舟完成签到 ,获得积分10
1分钟前
太清发布了新的文献求助10
1分钟前
江洋大盗发布了新的文献求助10
1分钟前
1分钟前
WWW完成签到 ,获得积分10
1分钟前
鲁丁丁发布了新的文献求助10
1分钟前
秋蚓完成签到 ,获得积分10
1分钟前
一切随风发布了新的文献求助50
1分钟前
超威蓝猫完成签到,获得积分10
1分钟前
ztayx完成签到 ,获得积分10
1分钟前
图治完成签到,获得积分10
1分钟前
rangersl1发布了新的文献求助10
1分钟前
1分钟前
图治发布了新的文献求助10
1分钟前
三横一竖发布了新的文献求助10
1分钟前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3976619
求助须知:如何正确求助?哪些是违规求助? 3520720
关于积分的说明 11204567
捐赠科研通 3257359
什么是DOI,文献DOI怎么找? 1798716
邀请新用户注册赠送积分活动 877897
科研通“疑难数据库(出版商)”最低求助积分说明 806613