Comparative Efficacy and Safety of Potassium‐Competitive Acid Blockers and Proton Pump Inhibitors for First‐Line Helicobacter pylori Eradication Therapy: A Systematic Review and Network Meta‐Analysis

ABSTRACT Background Given the increasing antibiotic resistance and the inadequate acid‐suppressing effects of proton pump inhibitors (PPIs), it is crucial to continuously optimize existing Helicobacter pylori ( H. pylori ) treatment regimens. This study aimed to evaluate the clinical efficacy and safety of novel potassium‐competitive acid blocker (P‐CAB)‐based eradication regimens compared with traditional PPI‐based regimens for the initial treatment of H. pylori . Materials and Methods We conducted a systematic review and network meta‐analysis, searching seven electronic databases for randomized controlled trials (RCTs) evaluating initial P‐CAB‐based H. pylori eradication therapy. The primary outcome was the H. pylori eradication rate. Secondary outcomes included adverse events and patient compliance. We synthesized the effect sizes of the trials using odds ratios (OR) and 95% confidence intervals (95% CI). Results A total of 54 RCTs involving 15,320 patients (74.9% male, mean age 30.2 years) were included in this study. In the intention‐to‐treat (ITT) analysis, VPZ‐HD‐dual, VPZ‐triple, and VPZ‐quadruple regimens demonstrated significantly higher eradication rates than PPI‐triple, PPI‐quadruple, and VPZ‐dual regimens. Similar trends were observed in the per‐protocol (PP) analysis. Subgroup analysis indicated that poor patient compliance significantly reduced eradication rates. Resistance to clarithromycin and metronidazole significantly weakened the eradication effects of PPI‐triple, TPZ‐triple, and VPZ‐triple regimens. Additionally, the eradication rates for 7‐day regimens were significantly lower than those for 14‐day or 10‐day regimens, but there was no significant difference between the eradication rates of 10‐day and 14‐day regimens. Notably, the risk of adverse events with VPZ‐HD‐dual was significantly lower than with VPZ‐quadruple. Conclusion Vonoprazan combined with high‐dose amoxicillin dual therapy not only provides satisfactory eradication rates but also exhibits lower adverse event rates and good patient compliance, indicating its potential as a promising regimen for further promotion.