化学
碳酸钾
亲核取代
药物化学
三乙胺
亲核芳香族取代
碳酸盐
二甲基亚砜
亲核细胞
硝基
芳基
碳酸二甲酯
铯
有机化学
取代反应
烷基
亚砜
甲醇
催化作用
作者
Azusa Kondoh,Hideki Yorimitsu,Koichiro Oshima
出处
期刊:Tetrahedron
[Elsevier]
日期:2006-03-01
卷期号:62 (10): 2357-2360
被引量:46
标识
DOI:10.1016/j.tet.2005.11.073
摘要
Treatment of nitroarenes having electron-withdrawing groups at the ortho or para position with alkanethiol in the presence of cesium carbonate in dimethyl sulfoxide at 25 °C leads to nucleophilic displacement of the nitro group with the alkylthio group. Cesium carbonate is superior to other bases such as potassium carbonate, sodium carbonate, and triethylamine. The cesium-mediated nucleophilic aromatic substitution reaction provides a mild yet powerful and user-friendly protocol for the synthesis of aryl sulfides.
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