光动力疗法
纳米传感器
材料科学
光敏剂
体内
氧气
纳米载体
生物相容性
纳米技术
氧传感器
纳米颗粒
介孔材料
生物物理学
化学
光化学
催化作用
生物化学
有机化学
冶金
生物技术
生物
作者
Zhenlu Yang,Jun Wen,Qing Wang,Yanjiao Li,Ying Zhao,Ying Tian,Xiaofen Wang,Xiongfeng Cao,Yunlei Zhang,Guangming Lu,Zhaogang Teng,Longjiang Zhang
标识
DOI:10.1021/acsami.8b16801
摘要
Real-time monitoring of oxygen consumption is beneficial to predict treatment responses and optimize therapeutic protocols for photodynamic therapy (PDT). In this work, we first demonstrate that deformable hollow mesoporous organosilica nanoparticles (HMONs) can be used to load [(Ru(dpp)3)]Cl2 for detecting oxygen (denoted as HMON-[(Ru(dpp)3)]Cl2). This nanoprobe shows significantly improved biocompatibility and high cellular uptake. In-vitro experiments demonstrate that the HMON-[(Ru(dpp)3)]Cl2 can sensitively detect oxygen changes between 1% and 20%. On this basis, photosensitizer chlorin e6 (Ce6) and [(Ru(dpp)3)]Cl2 are simultaneously loaded in the HMONs (denoted as HMON-Ce6-[(Ru(dpp)3)]Cl2) for real-time oxygen monitoring during photodynamic therapy. The HMON-Ce6-[(Ru(dpp)3)]Cl2 can reflects oxygen consumption in solution and cells in photodynamic therapy. Furthermore, the ability of the HMON-Ce6-[(Ru(dpp)3)]Cl2 nanosensor to monitor oxygen changes is demonstrated in tumor-bearing nude mice.
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