Argon: a noble, but not inert, treatment for brain trauma?

Traumatic brain injury (TBI) is an acquired neurological condition resulting from external mechanical forces and is a leading cause of morbidity and mortality worldwide.1 The global incidence of TBI is estimated to be 60 million cases annually.2 Although improvements in the clinical management of TBI have improved outcomes and reduced mortality, current treatments are largely supportive focussing on maintaining what are considered to be appropriate physiological levels of, for example, tissue oxygenation and ICP.