Characteristics and prognosis of primary malignant melanoma of the esophagus

医学 黑色素瘤 食管 危险系数 淋巴结 内科学 置信区间 淋巴结转移 放射科 癌症 存活率 肿瘤科 回顾性队列研究 放射治疗 比例危险模型 食管癌 生存分析 转移 阶段(地层学) 食管切除术 粘膜黑色素瘤 癌症研究
作者
Hengchi Chen,Qiang Fu,Kelin Sun
出处
期刊:Medicine [Wolters Kluwer]
卷期号:99 (28): e20957-e20957 被引量:10
标识
DOI:10.1097/md.0000000000020957
摘要

Primary malignant melanoma of esophagus (PMME) is a rare malignant tumor of esophagus. This study aimed to investigate the clinic pathologic characteristics and analyze the factors that might affect the prognosis of PMME patients.A total of 20 PMME patients who underwent surgical treatment in our hospital from 1975 to 2017 were analyzed. The clinical data, surgical and pathologic features of all patients were collected.For 20 PMME patients, the average age was 57.3 ± 10.7 years, and the male patients account for 75%. Most of the tumors (95%) were located in the middle and lower of the esophagus. There were 7 patients with primary tumor invasion beyond the muscular layer (T3 + T4) and 10 patients with lymph node metastasis (LNM). The median survival time of 20 patients was 12 months, and the 1-year and 5-year survival rates were 50% and 16.9%, respectively. The probability of LNM in tumors confined to submucosa (T1) and myometrium (T2) was lower than that in tumors with deeper invasion (T3, T4) (P = .035). Multivariate analysis showed that tumor node metastasis (TNM) staging was the independent prognostic factor for survival of PMME patients (hazard ratio [95% confidence interval], 4.15 [1.36-12.67]; P = .012).For PMME patients, tumors with deeper invasion were more likely to have LNM, and TNM staging was an independent predictor of prognosis for survival. Early detection of the disease and radical resection of the tumor are critical for better survival of the PMME patients.
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