微泡
癌症研究
上皮-间质转换
小RNA
膀胱癌
生物标志物
转移
间充质干细胞
癌症
外体
癌细胞
生物
医学
细胞生物学
内科学
基因
生物化学
作者
Xiaogang Yin,Xueping Zheng,Ming Liu,Dong Wang,Hui Sun,Yue Qiu,Jun Chen,Benkang Shi
摘要
Abstract Exosomes circulating in biological fluids have the potential to be utilized as cancer biomarkers and are associated with cancer progression and metastasis. MicroRNA (miR)‐663b has been found to be elevated in plasma from patients with bladder cancer (BC). However, the functional role of exosomal miR‐663b in BC processes remains unknown. Here, we isolated exosomes from plasma and found that the miR‐663b level was elevated in exosomes from plasma of patients with BC compared with healthy controls. Exosomal miR‐663b from BC cells promoted cell proliferation and epithelial–mesenchymal transition. Moreover, exosomal miR‐663b targeted Ets2‐repressor factor and acted as a tumor promoter in BC cells. Taken together, our findings suggested that exosomal miR‐663b is a promising potential biomarker and target for clinical detection and therapy in BC.
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