肿瘤生育
生育率
卵巢组织冷冻保存
保持生育能力
化疗
肿瘤科
卵巢癌
医学
疾病
指南
内科学
生物信息学
妇科
癌症
生物
病理
环境卫生
人口
作者
Jiaqiang Xiong,Liru Xue,Ya Li,Weicheng Tang,Dan Chen,Jinjin Zhang,Jun Dai,Su Zhou,Zhiyong Lu,Meng Wu,Shixuan Wang
出处
期刊:European journal of endocrinology
[Bioscientifica]
日期:2021-02-25
卷期号:184 (5): R177-R192
被引量:18
摘要
Fertility and ovarian protection against chemotherapy-associated ovarian damage has formed a new field called oncofertility, which is driven by the pursuit of fertility protection as well as good life quality for numerous female cancer survivors. However, the choice of fertility and ovarian protection method is a difficult problem during chemotherapy and there is no uniform guideline at present. To alleviate ovarian toxicity caused by anticancer drugs, effective methods combined with an individualized treatment plan that integrates an optimal strategy for preserving and restoring reproductive function should be offered from well-established to experimental stages before, during, and after chemotherapy. Although embryo, oocyte, and ovarian tissue cryopreservation are the major methods that have been proven effective and feasible for fertility protection, they are also subject to many limitations. Therefore, this paper mainly discusses the future potential methods and corresponding mechanisms for fertility protection in chemotherapy-associated ovarian damage.
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