神经化学
相容性(地球化学)
体内
纳米技术
抗坏血酸
神经元回路
神经元
化学
材料科学
神经科学
计算机科学
生物
食品科学
生物技术
复合材料
作者
Ping Yu,Huan Wei,Peipei Zhong,Yunfei Xue,Fei Wu,Yang Liu,Junjie Fei,Lanqun Mao
标识
DOI:10.1002/anie.202010195
摘要
Abstract The development of new principles and techniques with high neuronal compatibility for quantitatively monitoring the dynamics of neurochemicals is essential for deciphering brain chemistry and function but remains a great challenge. We herein report a neuron‐compatible method for in vivo neurochemical sensing by powering a single carbon fiber through spontaneous bipolar electrochemistry as a new sensing platform. By using ascorbic acid as a model target to prove the concept, we found that the single‐carbon‐fiber‐powered microsensor exhibited a good response, high stability and, more importantly, excellent neuronal compatibility. The microsensor was also highly compatible with electrophysiological recording, thus enabling the synchronous recording of both chemical and electrical signals. The sensing principle could be developed for in vivo monitoring of various neurochemicals in the future by rationally designing and tuning the electrochemical reactions at the two poles of the carbon fiber.
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