Role of local immune microenvironment of lung lesion in Mycobacterium tuberculosis infection

Tuberculosis (TB), an infectious disease caused by Mycobacterium tuberculosis (Mtb) infection, remains a major global concern. The activation of anti-TB immune responses is mediated by several complicated mechanisms, among which the local immune microenvironment at the disease site plays a crucial role. In this review, we discuss the roles of anti-TB immunity, Mtb immune escape and the elements at the local site of infection. Key words: Mycobacterium tuberculosis; Immune response; Immune microenvironment