Omalizumab for severe chronic spontaneous urticaria: Real-life experiences of 280 patients

Chronic spontaneous urticaria (CSU) is a debilitating disorder. Thus, well-defined therapeutic strategies are required to achieve a maximal remission and maintain quality of life. Half of all patients with severe CSU require high doses of antihistamines coupled with short courses of steroids.1 Cyclosporine A (CsA) is well established for its beneficial effect. However, frequent side effects and the fear of malignancies in long-term users required the development of better and safer therapeutic options.