Copper-catalyzed direct coupling of benzoxazin-2-ones with indoles for the synthesis of diverse 3-indolylbenzoxazin-2-ones: access to natural cephalandole A

Diverse and functionalized 3-indolyl benzo[b][1,4]oxazin-2-ones were synthesized via copper-catalyzed direct coupling of benzo[b][1,4]oxazin-2-one and indoles in air.