胰淀素
神经科学
老年斑
疾病
转基因小鼠
受体
淀粉样蛋白(真菌学)
调解人
阿尔茨海默病
细胞外
医学
转基因
生物
内科学
内分泌学
细胞生物学
病理
生物化学
糖尿病
小岛
基因
作者
Wenbin Fu,Aarti Patel,Ryuji Kimura,Rania Soudy,Jack H. Jhamandas
标识
DOI:10.1016/j.molmed.2017.06.003
摘要
Alzheimer'sdisease (AD) is a progressive neurodegenerative disorder, characterized by senile plaques constituting extracellular deposits of β-amyloid (Aβ) fibrils. Since Aβ accumulation in the brain is considered an early event preceding, by decades, cognitive dysfunction, disease-modifying treatments are aimed at facilitating clearance of this protein from the brain or ameliorating its toxic effects. Recent studies have identified the amylin receptor as a capable mediator of the deleterious actions of Aβ and furthermore, administration of amylin receptor-based peptides has been shown to improve spatial memory and learning in transgenic mouse models of AD. Here, by discussing available evidence, we posit that the amylin receptor could be considered a potential therapeutic target for AD, and present the rationale for using amylin receptor antagonists to treat this debilitating condition.
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