广告
药品
药物发现
候选药物
药理学
药代动力学
生化工程
计算生物学
性情
计算机科学
医学
生物信息学
生物
工程类
心理学
社会心理学
作者
Dermot F. McGinnity,Ken Grime
出处
期刊:Elsevier eBooks
[Elsevier]
日期:2017-01-01
卷期号:: 34-44
被引量:2
标识
DOI:10.1016/b978-0-12-409547-2.12365-0
摘要
An acceptable human pharmacokinetic (PK) profile increases the probability of a promising candidate drug becoming a successful therapy. The development of a mechanistic understanding of the disposition of candidate drugs toward confident predictions of key properties associated with human drug absorption, metabolism, distribution, and excretion is critical. This is achievable from a consideration of physicochemical properties, data from in vitro assays with human-derived material and from in vivo animal studies. This article targets medicinal chemists and drug design teams and provides general definitions of fundamental PK parameters together with the best-practiced characterization, optimization, and prediction strategies employed in the authors' laboratory.
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