选择(遗传算法)
药物发现
化学图书馆
计算生物学
编码(内存)
DNA
计算机科学
化学
遗传学
生物
人工智能
生物化学
小分子
作者
Bingbing Shi,Yu Zhou,Yiran Huang,Jian-Fu Zhang,Xiaoyu Li
标识
DOI:10.1016/j.bmcl.2016.12.025
摘要
DNA-encoded chemical library (DEL) has emerged as a powerful and versatile tool for ligand discovery in chemical biology research and in drug discovery. Encoding and selection methods are two of the most important technological aspects of DEL that can dictate the performance and utilities of DELs. In this digest, we have summarized recent advances on the encoding and selection strategies of DEL and also discussed the latest developments on DNA-encoded dynamic library, a new frontier in DEL research.
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