The human platelet alloantigen profile in blood donors from Amazonas, Brazil

基因分型 等位基因 血小板 免疫学 抗原 等位基因频率 血小板膜糖蛋白 抗体 生物 医学 基因型 遗传学 基因
作者
Clara Portela,Albert Schriefer,Sérgio Roberto Lopes Albuquerque,Renata Trentin Perdomo,Ana Flávia Alves Parente,Simone Schneider Weber
出处
期刊:Transfusion Medicine [Wiley]
卷期号:26 (6): 448-456 被引量:8
标识
DOI:10.1111/tme.12338
摘要

SUMMARY Background Human platelet antigens (HPAs) are alloantigens derived from polymorphisms in platelet‐surface glycoproteins. The occurrence of alloantibodies against HPAs can lead to platelet destruction and subsequent thrombocytopenia. Brazilians have a high rate of racial admixture, and the knowledge of HPA polymorphisms in particular donors from north Brazil, who have a large Amerindian influence, is a relevant strategy to prevent alloimmunisation. Objective Our aim was investigate the HPA allele's frequencies in the Amazonas blood donors. Methods We performed HPA genotyping among 200 Amazonas blood donors by microarray for 11 HPA biallelic systems, including six of the most clinically significant systems (HPA‐1 to ‐5 and ‐15) and five others (HPA‐6 to ‐9 and ‐11) that have been also associated with alloimmunisation, amounting to 22 HPA alleles. Results The obtained allele frequencies were compared with data of 38 populations worldwide to determine the hierarchical relationship and estimated the probability of mismatch platelets. The allele frequencies were 0·862 for HPA‐1 a , 0·137 for HPA‐1 b , 0·852 for HPA‐2 a , 0·147 for HPA‐2 b , 0·665 for HPA‐3 a , 0·335 for HPA‐3 b , 0·995 for HPA‐4 a , 0·005 for HPA‐4 b , 0·892 for HPA‐5 a , 0·107 for HPA‐5 b , 0·997 for HPA‐9 a , 0·005 for HPA‐9 b , 0·502 for HPA‐15 a and 0·497 for HPA‐15 b . The incompatibility risks are higher for HPA‐15 and HPA‐3, followed by HPA‐1, ‐2 and ‐5. Conclusion We found differences among populations worldwide, and it is interesting to note the indigenous and European influences in this region, reinforcing the heterogeneity in the ancestry of Brazilians. The results will be helpful in providing information for platelet transfusion to avoid alloimmunisation.
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