Association Between Depression and Physical Conditions Requiring Hospitalization

医学 萧条(经济学) 危险系数 混淆 生命银行 队列研究 队列 人口 置信区间 记录链接 入射(几何) 人口学 内科学 环境卫生 遗传学 物理 社会学 生物 光学 经济 宏观经济学
作者
Philipp Frank,G. David Batty,Jaana Pentti,Markus Jokela,Lydia Poole,Jenni Ervasti,Jussi Vahtera,Glyn Lewis,Andrew Steptoe,Mika Kivimäki
出处
期刊:JAMA Psychiatry [American Medical Association]
卷期号:80 (7): 690-690 被引量:33
标识
DOI:10.1001/jamapsychiatry.2023.0777
摘要

Importance Depression is associated with an increased risk of physical illness, but the most common causes of hospitalization among people with depression are unclear. Objective To examine the association of depression with an array of physical conditions requiring hospital treatment. Design, Setting, and Participants In this outcomewide prospective multicohort study, primary analysis was based on data from the UK Biobank, a population-based study in the United Kingdom. Analyses were repeated in an independent data set of 2 cohorts in Finland, a population-based study and an occupational cohort. Data analysis was conducted between April and September 2022. Exposures Self-reported depression, recurrent severe major depression, recurrent moderate major depression, and a single major depressive episode. Main Outcomes and Measures A total of 77 common health conditions ascertained from linkage data to national hospital and mortality registries. Results The analytical sample of UK Biobank participants consisted of 130 652 individuals (71 565 women [54.8%]; 59 087 men [45.2%]; mean [SD] age at baseline, 63.3 [7.8] years). The pooled data from the Finnish replication cohorts included 109 781 participants (82 921 women [78.6%]; 26 860 men [21.4%]; mean [SD] age, 42 [10.8] years). In the main analysis, severe/moderately severe depression was associated with the incidence of 29 nonoverlapping conditions requiring hospital treatment during a 5-year follow-up. Twenty-five of these associations remained after adjustment for confounders and multiple testing (adjusted hazard ratio [HR] range, 1.52-23.03) and were confirmed in the analysis of the Finnish cohorts. These included sleep disorders (HR, 5.97; 95% CI, 3.27-10.89), diabetes (HR, 5.15; 95% CI, 2.52-10.50), ischemic heart disease (HR, 1.76; 95% CI, 1.36-2.29), chronic obstructive bronchitis (HR, 4.11; 95% CI, 2.56-6.60), bacterial infections (HR, 2.52; 95% CI, 1.99-3.19), back pain (HR, 3.99; 95% CI, 2.96-5.38), and osteoarthritis (HR, 1.80; 95% CI, 1.46-2.20). The highest cumulative incidence was observed for endocrine and related internal organ diseases (245 per 1000 persons with depression; risk difference relative to unaffected individuals: 9.8%), musculoskeletal diseases (91 per 1000 persons; risk difference, 3.7%), and diseases of the circulatory system and blood (86 per 1000 persons; risk difference, 3.9%). The cumulative incidence was lower for hospital-treated mental, behavioral, and neurological disorders (20 in 1000 persons; risk difference, 1.7%). Depression was also associated with disease progression in people with prevalent heart disease or diabetes, and for 12 conditions, there was evidence of a bidirectional relationship. Conclusions and Relevance In this study, the most common causes of hospitalization in people with depression were endocrine, musculoskeletal, and vascular diseases, not psychiatric disorders. These findings suggest that depression should be considered as a target for the prevention of physical and mental disease.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
可爱的函函应助lishuai采纳,获得10
1秒前
1秒前
wjy完成签到,获得积分10
1秒前
ylq发布了新的文献求助10
1秒前
wendinfgmei应助wang1343259150采纳,获得10
2秒前
Lucas应助Accpted河豚采纳,获得10
2秒前
夏夏发布了新的文献求助10
2秒前
haha完成签到,获得积分10
2秒前
今后应助中宝采纳,获得10
3秒前
3秒前
3秒前
赘婿应助复杂听筠采纳,获得30
3秒前
tiantian发布了新的文献求助10
4秒前
搜集达人应助旦丁洋采纳,获得10
4秒前
李爱国应助缓慢孤菱采纳,获得10
4秒前
bryce-jiang完成签到,获得积分10
4秒前
小刘哥加油完成签到 ,获得积分10
5秒前
5秒前
虚幻故事发布了新的文献求助10
5秒前
灰灰完成签到,获得积分10
5秒前
河豚不擦鞋完成签到 ,获得积分10
5秒前
英姑应助cslghe采纳,获得10
5秒前
Demon_1996发布了新的文献求助30
6秒前
万象发布了新的文献求助30
6秒前
赘婿应助slj采纳,获得10
6秒前
SYLH应助单薄的忆枫采纳,获得10
6秒前
兴奋奇异果完成签到,获得积分10
6秒前
慕青应助粗暴的宛筠采纳,获得10
6秒前
朴志晟发布了新的文献求助10
7秒前
羽翼完成签到,获得积分10
8秒前
茶送白粥完成签到,获得积分10
8秒前
8秒前
cc发布了新的文献求助10
8秒前
9秒前
chaoqi完成签到,获得积分10
9秒前
WIK完成签到,获得积分10
10秒前
领导范儿应助hwy采纳,获得10
10秒前
11秒前
乖乖猫完成签到,获得积分10
11秒前
高分求助中
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
Effective Learning and Mental Wellbeing 300
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3974602
求助须知:如何正确求助?哪些是违规求助? 3519026
关于积分的说明 11196787
捐赠科研通 3255127
什么是DOI,文献DOI怎么找? 1797693
邀请新用户注册赠送积分活动 877100
科研通“疑难数据库(出版商)”最低求助积分说明 806130