Presence and risks of polycyclic aromatic hydrocarbons, dioxins and dioxin-like PCBs in dietary plant supplements as elucidated by a combined DR CALUX® bioassay and GC-HRMS based approach

化学 生物测定 环境化学 多氯代二苯并呋喃 多环芳烃 芳香烃受体 污染 多氯联苯 毒性当量因子 持久性有机污染物 食品科学 碳氢化合物 有机化学 生物化学 生物 生态学 遗传学 基因 转录因子
作者
Felicia Akuamoa,L.A.P. Hoogenboom,Yoran Weide,Guido van der Weg,Ivonne M. C. M. Rietjens,Toine F. H. Bovee
出处
期刊:Food Additives & Contaminants: Part A [Taylor & Francis]
卷期号:39 (9): 1576-1590 被引量:4
标识
DOI:10.1080/19440049.2022.2094473
摘要

Plant-based dietary supplements may contain undesirable contaminants such as polycyclic aromatic hydrocarbons, dioxins and dioxin-like polychlorinated biphenyls (dl-PCBs) due to the sources of raw materials or processing methods used. The presence of these contaminants in a series of herbal supplements sold on the Ghanaian market for improving sexual performance was examined using the DR CALUX® bioassay in combination with GC-HRMS analysis. Overall, cell responses at 4 and 48 h exposure to extracts prepared without an acid-silica clean-up were relatively higher than the responses obtained from extracts prepared with an acid-silica clean-up. This indicated that the 40 supplements contained only low levels of stable aryl hydrocarbon receptor (AhR) agonists like polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) and dl-PCBs, while some contained substantial amounts of less stable AhR-agonists. Ten supplements selected for confirmation with GC-HRMS analysis contained PCDD/Fs and dl-PCBs at levels ranging from 0.01 to 0.19 pg toxic equivalent (TEQ)/g only, while the level of the sum of 4 polycyclic aromatic hydrocarbons (Σ4PAHs) representing less stable AhR agonists, ranged from not detected (ND) to 25.5 ng/g. These concentrations were in line with the responses observed in the DR CALUX® bioassay. The concentration of PCDD/Fs and dl-PCBs corresponded to estimated daily intakes (EDIs) ranging from 0.01 to 1.20 pg TEQ/day, or 0.001 to 0.12 pg TEQ/kg bw/week for a 70 kg bw consumer, which was below the established tolerable weekly intake (TWI) of 2 pg TEQ/kg bw/week, thus indicating low concern for consumers' health. Similarly, the EDIs based on the detected Σ4PAHs in supplements ranged from 7.2 to 111 ng/day, or 0.1 to 1.6 ng/kg bw/day, which corresponded to MOE values above 10,000, indicating a low health concern.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
FleeToMars完成签到 ,获得积分10
2秒前
在水一方应助dongdong采纳,获得10
3秒前
3秒前
萧萧发布了新的文献求助10
4秒前
bkagyin应助GQL采纳,获得10
5秒前
6秒前
上官若男应助牛牛牛采纳,获得10
6秒前
量子星尘发布了新的文献求助10
7秒前
Hello应助萧萧采纳,获得10
8秒前
嗖_啪_发布了新的文献求助10
9秒前
10秒前
pipipi完成签到,获得积分10
10秒前
11秒前
小熊猫发布了新的文献求助10
12秒前
Adenine完成签到 ,获得积分10
12秒前
lililili关注了科研通微信公众号
13秒前
deletelzr完成签到,获得积分10
14秒前
14秒前
牛牛牛发布了新的文献求助10
17秒前
18秒前
19秒前
djiwisksk66应助松松老师采纳,获得10
21秒前
Alice完成签到,获得积分10
22秒前
学术小牛发布了新的文献求助10
22秒前
djiwisksk66应助ll采纳,获得10
23秒前
24秒前
26秒前
28秒前
30秒前
31秒前
33秒前
33秒前
2896186249发布了新的文献求助10
34秒前
35秒前
xiaofeiyan发布了新的文献求助20
36秒前
唠叨的以柳完成签到,获得积分20
38秒前
陈骏康发布了新的文献求助10
39秒前
39秒前
rnf发布了新的文献求助10
40秒前
40秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Picture Books with Same-sex Parented Families: Unintentional Censorship 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
A Preliminary Study on Correlation Between Independent Components of Facial Thermal Images and Subjective Assessment of Chronic Stress 500
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3971516
求助须知:如何正确求助?哪些是违规求助? 3516229
关于积分的说明 11181488
捐赠科研通 3251405
什么是DOI,文献DOI怎么找? 1795821
邀请新用户注册赠送积分活动 876051
科研通“疑难数据库(出版商)”最低求助积分说明 805245