光降解
酞菁
催化作用
G-四倍体
化学
光化学
锌
DNA
光催化
组合化学
有机化学
生物化学
作者
Yusuke Odahara,Atsuya Momotake,Yuri Syokaku,Yasuhiko Yamamoto
标识
DOI:10.1002/cbic.202400197
摘要
Water-soluble phthalocyanine (Pc) derivatives have been regarded as potential G-quadruplex (G4) nucleic acid-targeting ligands for anticancer therapy and have been extensively studied as effective photosensitizers for photodynamic therapy (PDT). Understanding how photosensitizers interact with nucleic acids and the subsequent photolytic reactions is essential for deciphering the initial steps of PDT, thereby aiding in the development of new photosensitizing agents. In this study, we found that red-light irradiation of a mixture of a Zn(II) Pc derivative and an all-parallel G4 DNA leads to catalytic and selective photodegradation of the DNA by reactive oxygen species (ROS) generated from the Zn(II) Pc derivative bound to DNA through a reaction mechanism similar to that of an enzyme reaction. This finding provides a novel insight into the molecular design of a photosensitizer to enhance its PDT efficacy.
科研通智能强力驱动
Strongly Powered by AbleSci AI