细胞生物学
应力颗粒
生物
化学
内分泌学
内科学
遗传学
医学
基因
翻译(生物学)
信使核糖核酸
作者
Xuejing Zhang,Lulu Han,Jinxiu Hou,Huiyu Yang,Haiyan Xu,Guosheng Li,Qiang Shu,Deyu Zhu,Yi Zheng,Chengjiang Gao
出处
期刊:Cell Reports
[Elsevier]
日期:2024-06-01
卷期号:43 (6): 114248-114248
标识
DOI:10.1016/j.celrep.2024.114248
摘要
Cyclic GMP-AMP synthase (cGAS) undergoes liquid-liquid phase separation (LLPS) to trigger downstream signaling upon double-stranded DNA (dsDNA) stimulation, and the condensed cGAS colocalizes with stress granules (SGs). However, the molecular mechanism underlying the modulation of cGAS activation by SGs remains elusive. In this study, we show that USP8 is localized to SGs upon dsDNA stimulation and potentiates cGAS-stimulator of interferon genes (STING) signaling. A USP8 inhibitor ameliorates pathological inflammation in Trex1
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