DNA-Assembled SERS-Active Multimeric Nanoparticle Structures

In the last few decades, deoxyribonucleic acid (DNA) molecules have been utilized as a scaffolding material for nanoscale objects due to their intrinsic nanoscale dimension, predictable interactions in the secondary structure, and ease of synthesis. Diverse plasmonic nanoparticles and photonic elements are organized by using DNA-based scaffolds with high precision. The surface-enhanced Raman scattering technique that relies on the proper spatial organization of plasmonic nanoparticles has greatly benefited from DNA-directed nanoparticle structures. Due to the rapid progress of this domain, a proper understanding of the existing literature is required. This review provides a background and current state-of-the-art in this field of DNA-assembled SERS-active multimeric nanoparticle structures. We also discuss the potential pitfalls of this method that restrict further technological progress.