帕金森病
血脑屏障
神经科学
医学
疾病
心理学
病理
中枢神经系统
作者
Carmen Gasca‐Salas,Jose Á. Pineda‐Pardo,Marta del Álamo,Tamara Jiménez,Clara Trompeta,Gabriella Toltsis,L. García-Cañamaque,Beatriz Fernández‐Rodríguez,Michele Matarazzo,Isabel Plaza de las Heras,Elena Natera‐Villalba,Raúl Martínez‐Fernández,Alicia Duque,Santiago Ruiz de Aguiar,Javier Blesa,Itay Rachmilevich,José Á. Obeso
标识
DOI：10.1136/jnnp-2023-332967
摘要
The nigrostriatal system is especially vulnerable to neurodegeneration in Parkinson's disease (PD) and the blood-brain barrier (BBB) is a limiting factor for delivery of therapeutic agents to the brain. This pilot study aimed to demonstrate safety, feasibility and tissue penetration (by 18F-Choline-positron emission tomography (PET)) of MR-guided focused ultrasound (MRgFUS) simultaneous BBB opening (BBB-O) in the substantia nigra (SN) and putamen in PD.
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