Peroxidase‐Mimetic Iron Silicate Nanosheets Coordinated with Indocyanine Green for Enhanced Anti‐Tumor Therapy

Abstract The versatile element composition and multifunctional properties of biodegradable silicates have attracted significant attention in cancer therapeutics. However, their application as nanozymes is often limited by suboptimal catalytic efficiency and insufficient intratumoral retention. In this study, the hydrothermal synthesis of iron silicate (FeSi) nanosheets are reported exhibiting exceptional peroxidase (POD)‐like activity (136.7 U mg −1 ), outperforming most reported iron‐based nanozymes. Density functional theory calculations revealed that the introduction of Si into the catalyst enhances H 2 O 2 adsorption and dissociation of Fe sites, leading to superior POD performance. Furthermore, the FeSi nanosheets are modified with Indocyanine Green (ICG) to facilitate targeted aggregation‐potentiated therapy. The integration of ICG improved tumor penetration and retention of the FeSi nanosheets, significantly increasing their reactive oxygen species production and bolstering therapeutic efficacy.