Advances of Ugi reaction in natural product synthesis

The Ugi multicomponent reaction represents a highly efficient synthetic transformation, wherein all four reactants (isocyanides, amine, aldehyde or ketone and a nucleophile) are combined in one pot under mild conditions. This reaction exhibits remarkable synthetic prowess, allowing for the rapid assembly of diverse and potent building blocks in organic chemistry and natural product synthesis. This minireview focuses on Ugi multicomponent reactions and highlights their applicability to the total synthesis of natural products and analogs. This minireview focuses on recent applications of Ugi reactions in total syntheses of natural products. The Ugi reaction enables facile assemble of complex acylaminoamides motif in a single step, rendering it an appealing tool for organic chemists due to its versatility and user-friendly nature. Ongoing research endeavors are continuously broadening the horizons of the Ugi reaction, allowing for exploration into novel and challenging synthetic targets.