基质金属蛋白酶
发病机制
纤维化
肾脏疾病
细胞外基质
肾病
肾脏发育
肾
肾损伤
MMP9公司
明胶酶
细胞生物学
医学
生物信息学
生物
内科学
病理
内分泌学
生物化学
基因
下调和上调
胚胎干细胞
糖尿病
作者
Guiying Pang,Ling Ye,Yinxiao Jiang,Yilin Wu,Rufeng Zhang,Hongxu Yang,Yi Yang
标识
DOI:10.1016/j.cellsig.2024.111312
摘要
Matrix metalloproteinases (MMPs) are a group of zinc-dependent proteolytic metalloenzymes that are involved in numerous pathological conditions, including nephropathy. MMP9, a member of the MMPs family, is categorized as a constituent of the gelatinase B subgroup, and its involvement in extracellular matrix (ECM) remodeling and renal fibrosis highlights its importance in the development and progression of renal diseases. The exact role of MMP9 in the development of kidney diseases is still controversial. This study investigated the dual role of MMP9 in kidney injury, discussing its implications in the pathogenesis of kidney diseases and investigating the design and mechanism of MMP9 inhibitors based on previous studies. This study provides an effective basis for the development of novel and selective MMP9 inhibitors for treating renal diseases.
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