甾醇调节元件结合蛋白
转录因子
甾醇
生物化学
DNA结合蛋白
细胞生物学
化学
阿尔茨海默病
疾病
生物
基因
胆固醇
内科学
医学
作者
Siyuan Liu,Xinzhu Li,Panpan Fan,Yujia Gu,Aifeng Yang,Weiyi Wang,Lijun Zhou,Huanhua Chen,Fangyuan Zheng,Junjie Lin,Zihua Xu,Qingchun Zhao
标识
DOI:10.1016/j.biopha.2024.117575
摘要
Sterol regulatory element binding proteins (SREBPs) are a series of cholesterol-related transcription factors. Their role in regulating brain cholesterol biosynthesis, amyloid accumulation, and tau tangles formation has been intensively studied in protein-protein interaction analysis based on genes in clinical databases. SREBPs play an important role in maintaining cholesterol homeostasis in the brain. There are three subtypes of SREBPs, SREBP-1a stimulates the expression of genes related to cholesterol and fatty acid synthesis, SREBP-1c stimulates adipogenesis, and SREBP-2 stimulates cholesterol synthase and LDL receptors. SREBP-2 is activated in response to cholesterol depletion and stimulates a compensatory upregulation of cholesterol uptake and synthesis. Previous studies have shown that inhibition of SREBP-2 reduces cholesterol and amyloid accumulation, and new research suggests that SREBPs play a multifaceted role in Alzheimer's disease. Here, we highlight the importance of SREBPs in AD, in terms of multiple pathways regulating cholesterol in the brain, and primarily demonstrate the potential of SREBP-2 inhibitors. There was a trend towards a significant increase in the expression levels of different SREBP isoforms in AD patients compared to healthy controls. Therefore, there is a close link between SREBPs and AD, and this review analyses the potential role of SREBPs in the treatment of AD. In addition, we systematically reviewed the research progress of SREBPs in AD, and this review will provide more innovative insights into the pathogenesis and treatment of AD and new strategies for drug development in AD.
科研通智能强力驱动
Strongly Powered by AbleSci AI