Association of plasma neurofilament light chain and Lipoprotein-related phospholipase A2 with motor subtypes of Parkinson’s disease

神经丝 疾病 神经科学 联想(心理学) 医学 内科学 生物 心理学 免疫组织化学 心理治疗师
作者
Jinghui Zhang,Mengmeng Dong,Zhen Li,Zhuo Li,Rui Zhang,Meili Deng,Yanlin Wang,Tingyu Cao,Qingqing Shi,Pengcheng Huang,Tao Huang,H F Wang,Wei Liu,Victor Wei Zhang,Qi Li,Tao Yan,Xiaodong Zhu
出处
期刊:Neuroscience Letters [Elsevier]
卷期号:: 138011-138011
标识
DOI:10.1016/j.neulet.2024.138011
摘要

Neurofilament light chain (NfL) levels were reliable biomarkers of neurodegeneration in Parkinson's disease (PD). Lipoprotein-related Phospholipase A2(Lp-PLA2) levels have also been increasingly studied in PD. We aimed to explore the association of plasma NfL and Lp-PLA2 with the diagnosis, motor subtypes and disease severity of PD. Plasma NfL and Lp-PLA2 were assayed separately in 106 participants (74 PD and 32 healthy controls, HC). The motor subtypes of PD were classified according to the MDS-UPDRS components, and motor and non-motor manifestations of patients were also evaluated. Subsequently, correlation analyses were performed. The plasma NfL levels were higher in the PD than HC, and were positively correlated with age, UPDRS II, UPDRS III and the modified Hoehn and Yahr staging scale (H&Y stage) in the PD. Moreover, plasma Lp-PLA2 levels were lower in the PD than HC, and were positively correlated with Parkinson's Disease Quality of Life Questionnaire (PDQ-39) in the PD. For further distinguishing tremor-dominant (TD) from postural instability and gait difficulty-dominant (PIGD), plasma Lp-PLA2 levels were higher in the TD than PIGD, but there was no significant difference in NfL. plasma Lp-PLA2 levels were positively correlated with UPDRS I, Hamilton Anxiety Rating Scale (HAMA) and PDQ-39 in the TD. These resultssuggest that NfL and Lp-PLA2 may be potential biomarkers for the diagnosis of PD. We first demonstrated the potential utility of plasma Lp-PLA2 in differentiating motor subtypes. These findings deserve further evidence in larger PD cohorts.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
2秒前
研友_VZG7GZ应助义气的三德采纳,获得10
2秒前
赤侯完成签到,获得积分10
3秒前
quanjia关注了科研通微信公众号
3秒前
Darren发布了新的文献求助10
4秒前
Anna完成签到 ,获得积分10
4秒前
烟花应助熠烁采纳,获得10
5秒前
5秒前
淡然的浩宇完成签到,获得积分10
6秒前
纯情的谷云完成签到,获得积分10
7秒前
刚少kk完成签到,获得积分10
7秒前
matafeiyan完成签到 ,获得积分10
8秒前
8秒前
ding应助QYW采纳,获得10
9秒前
10秒前
早早发布了新的文献求助10
11秒前
12秒前
林稚完成签到 ,获得积分10
12秒前
12秒前
YG完成签到 ,获得积分20
12秒前
rover完成签到 ,获得积分10
12秒前
BAI完成签到,获得积分10
13秒前
共享精神应助九点一定起采纳,获得10
14秒前
NexusExplorer应助淡然的浩宇采纳,获得10
15秒前
15秒前
15秒前
我是老大应助开心采纳,获得10
16秒前
18秒前
田様应助早早采纳,获得10
19秒前
lynn发布了新的文献求助200
20秒前
insane发布了新的文献求助10
20秒前
鳗鱼凡旋发布了新的文献求助10
20秒前
温暖芸发布了新的文献求助10
20秒前
dd完成签到,获得积分10
21秒前
22秒前
熠烁发布了新的文献求助10
25秒前
xsq86完成签到,获得积分10
26秒前
zhw297发布了新的文献求助10
28秒前
30秒前
30秒前
高分求助中
Sustainability in Tides Chemistry 2800
Kinetics of the Esterification Between 2-[(4-hydroxybutoxy)carbonyl] Benzoic Acid with 1,4-Butanediol: Tetrabutyl Orthotitanate as Catalyst 1000
The Young builders of New china : the visit of the delegation of the WFDY to the Chinese People's Republic 1000
Rechtsphilosophie 1000
Bayesian Models of Cognition:Reverse Engineering the Mind 888
Handbook of Qualitative Cross-Cultural Research Methods 600
Very-high-order BVD Schemes Using β-variable THINC Method 568
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3137511
求助须知:如何正确求助?哪些是违规求助? 2788516
关于积分的说明 7786944
捐赠科研通 2444783
什么是DOI,文献DOI怎么找? 1300018
科研通“疑难数据库(出版商)”最低求助积分说明 625770
版权声明 601023